Personal Discovery Process for your patient

The Personal Discovery Process (PDP) allows you to match your patient’s cancer with the most tailored combination treatment.

Why choose the Personal Discovery Process?

The Personal Discovery Process is the world’s only strategy using real patients’ avatars for drug screening. It identifies the precise combination of FDA-approved drugs (including non-cancer drugs) that works optimally on your patient’s specific tumour, mirroring its genetic complexity and increasing the prospects of an efficient treatment while also reducing toxicity and side effects.

Sequence

PDP first identifies all gene mutations associated with the patient’s tumour via whole exome sequencing. DNA can be extracted from either a new biopsy or from a previous histologic sample used for diagnosis as well as a blood sample.

Identify

This complex oncogenetic network is modelled in the intestine of the fruit fly, Drosophila melanogaster, to generate a personalised fly avatar that carries the patient cancer.

Screen

Up to 400,000 avatar flies are grown for each patient and used to screen ~2000 drugs and drug combinations covering the full FDA library of approved compounds.

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Who can benefit from the Personal Discovery Process?

The Personal Discovery Process (PDP) can be employed for patients with gastro-intestinal (GI) cancers, including tumours of the upper (e.g. oesophagus) and lower (e.g. colorectal) GI tract, as well as for patients with lung cancers. Patients with rare cancers or tumours of unknown origin for which no standard protocol has been established could also greatly benefit from PDP.
Please get in touch with us to find out if PDP is right for your specific cancer.

PDP can help identify optimal treatments for patients with early cancers as well as for patients with difficult to treat advanced cancers, who have exhausted treatment options with conventional approaches.

Finally, people with pre-malignant gut lesions can also benefit from PDP. The presence of adenomas in the digestive tract is well correlated with the development of colorectal cancer in the following years. Non cancer patients with this feature can greatly benefit from having a pre-avatar model already built and ready to provide a treatment recommendation when required.

A comprehensive and personalised oncology tool made simple

How long does the Personal Discovery Process take?


PDP can take 2 - 4 months after tumour and blood sequencing results are available. The difference in time reflects differences in tumour type, complexity, the number of drugs and drug combinations tested until the final cocktail is identified.